Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease

Globoid cell leukodystrophy (Krabbe disease) is a fatal neurodegenerative, demyelinating disease caused by dysfunctional activity of galactosylceramidase (GALC), leading to the accumulation of glycosphingolipids including psychosine.While oligodendrocytes have been extensively studied due to their high levels of GALC, the contribution of astrocytes

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Intertemporal Static and Dynamic Optimization of Synthesis, Design, and Operation of Integrated Energy Systems of Ships

Fuel expenses constitute the largest part of the operating cost of a merchant ship.Integrated energy systems that cover all energy loads with low fuel Related Parts consumption, while being economically feasible, are increasingly studied and installed.Due to the large variety of possible configurations, design specifications, and operating conditio

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